Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion

Nucleotide base editors in plants have been limited to conversion of cytosine to thymine. Here, we describe a new plant adenine base editor based on an evolved tRNA adenosine deaminase fused to the nickase CRISPR/Cas9, enabling A•T to G•C conversion at frequencies up to 7.5% in protoplasts and 59.1%...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Li, Chao, Zong, Yuan, Wang, Yanpeng, Jin, Shuai, Zhang, Dingbo, Song, Qianna, Zhang, Rui, Gao, Caixia
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
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Method
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972399/
https://ncbi.nlm.nih.gov/pubmed/29807545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1443-z
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