Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensively Drug-Resistant Pseudomonas aeruginosa

Polymyxins are increasingly used as a last-resort class of antibiotics against extensively drug-resistant (XDR) Gram-negative bacteria. However, resistance to polymyxins can emerge with monotherapy. As nephrotoxicity is the major dose-limiting factor for polymyxin monotherapy, dose escalation to sup...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Lin, Yu-Wei, Yu, Heidi H., Zhao, Jinxin, Han, Mei-Ling, Zhu, Yan, Akter, Jesmin, Wickremasinghe, Hasini, Walpola, Hasini, Wirth, Veronika, Rao, Gauri G., Forrest, Alan, Velkov, Tony, Li, Jian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971615/
https://ncbi.nlm.nih.gov/pubmed/29632010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00028-18
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