Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa

Polymyxins are used as a last-resort class of antibiotics against multidrug-resistant (MDR) Gram-negative Pseudomonas aeruginosa. As polymyxin monotherapy is associated with potential development of resistance, combination therapy is highly recommended. This study investigated the mechanism underlyi...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lin, Yu-Wei, Han, Mei-Ling, Zhao, Jinxin, Zhu, Yan, Rao, Gauri, Forrest, Alan, Song, Jiangning, Kaye, Keith S., Hertzog, Paul, Purcell, Anthony, Creek, Darren, Zhou, Qi Tony, Velkov, Tony, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785843/
https://ncbi.nlm.nih.gov/pubmed/31632279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01146
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