Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study employ...

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Detalhes bibliográficos
Publicado no:mSystems
Main Authors: Han, Mei-Ling, Zhu, Yan, Creek, Darren J., Lin, Yu-Wei, Gutu, Alina D., Hertzog, Paul, Purcell, Tony, Shen, Hsin-Hui, Moskowitz, Samuel M., Velkov, Tony, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325167/
https://ncbi.nlm.nih.gov/pubmed/30637340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00149-18
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