Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels

The imidazopyridines are a promising new class of antitubercular agents with potent activity in vitro and in vivo. We isolated mutants of Mycobacterium tuberculosis resistant to a representative imidazopyridine; the mutants had large shifts (>20-fold) in MIC. Whole-genome sequencing revealed muta...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: O'Malley, Theresa, Alling, Torey, Early, Julie V., Wescott, Heather A., Kumar, Anuradha, Moraski, Garrett C., Miller, Marvin J., Masquelin, Thierry, Hipskind, Philip A., Parish, Tanya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971599/
https://ncbi.nlm.nih.gov/pubmed/29632008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02439-17
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