First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae

Penicillin-binding proteins (PBPs) are the high-affinity target sites of all β-lactam antibiotics in bacteria. It is well known that each β-lactam covalently binds to and thereby inactivates different PBPs with various affinities. Despite β-lactams serving as the cornerstone of our therapeutic armam...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Sutaria, Dhruvitkumar S., Moya, Bartolome, Green, Kari B., Kim, Tae Hwan, Tao, Xun, Jiao, Yuanyuan, Louie, Arnold, Drusano, George L., Bulitta, Jürgen B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971569/
https://ncbi.nlm.nih.gov/pubmed/29712652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00282-18
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