Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited data on OM permeability especially in K. pneumoniae. Here, w...

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Udgivet i:mBio
Main Authors: Kim, Tae Hwan, Tao, Xun, Moya, Bartolome, Jiao, Yuanyuan, Basso, Kari B., Zhou, Jieqiang, Lang, Yinzhi, Sutaria, Dhruvitkumar S., Zavascki, Alexandre P., Barth, Afonso L., Reeve, Stephanie M., Schweizer, Herbert P., Deveson Lucas, Deanna, Boyce, John D., Bonomo, Robert A., Lee, Richard E., Shin, Beom Soo, Louie, Arnold, Drusano, George L., Bulitta, Jürgen B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018653/
https://ncbi.nlm.nih.gov/pubmed/32047131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03189-19
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