Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift

Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli induce Ca(2+)-dependent formation of the mitochondrial permeability transition pore (MPTP), a solute channel modulated by cyclophilin D (CypD), the formation of which causes ATP depletion and necrosis. Oxidativ...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Armstrong, Jane A., Cash, Nicole J., Ouyang, Yulin, Morton, Jack C., Chvanov, Michael, Latawiec, Diane, Awais, Muhammad, Tepikin, Alexei V., Sutton, Robert, Criddle, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971444/
https://ncbi.nlm.nih.gov/pubmed/29626097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003200
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