TRO40303 Ameliorates Alcohol-Induced Pancreatitis Through Reduction of Fatty Acid Ethyl Ester–Induced Mitochondrial Injury and Necrotic Cell Death

OBJECTIVES: Mitochondrial permeability transition pore inhibition is a promising approach to treat acute pancreatitis (AP). We sought to determine (i) the effects of the mitochondrial permeability transition pore inhibitor 3,5-seco-4-nor-cholestan-5-one oxime-3-ol (TRO40303) on murine and human panc...

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Detalhes bibliográficos
Publicado no:Pancreas
Main Authors: Javed, Muhammad Ahsan, Wen, Li, Awais, Muhammad, Latawiec, Diane, Huang, Wei, Chvanov, Michael, Schaller, Sophie, Bordet, Thierry, Michaud, Magali, Pruss, Rebecca, Tepikin, Alexei, Criddle, David, Sutton, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753827/
https://ncbi.nlm.nih.gov/pubmed/29200128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000953
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