ZEB1 inhibition sensitizes cells to the ATR inhibitor VE-821 by abrogating epithelial–mesenchymal transition and enhancing DNA damage

The ataxia-telangiectasia-mutated (ATM) and rad3-related (ATR) checkpoint pathway plays an essential role in modulating cellular responses to replication stress and DNA damage to maintain genomic stability. In various tumors, cancer cells have increased dependence on ATR signaling for survival, maki...

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Publicado en:Cell Cycle
Main Authors: Song, Na, Jing, Wei, Li, Ce, Bai, Ming, Cheng, Yu, Li, Heming, Hou, Kezuo, Li, Yanrong, Wang, Kai, Li, Zhi, Liu, Yunpeng, Qu, Xiujuan, Che, Xiaofang
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
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Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969561/
https://ncbi.nlm.nih.gov/pubmed/29157079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1404206
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