Non-competitive cyclic peptides for targeting enzyme–substrate complexes

Affinity reagents are of central importance for selectively identifying proteins and investigating their interactions. We report on the development and use of cyclic peptides, identified by mRNA display-based RaPID methodology, that are selective for, and tight binders of, the human hypoxia inducibl...

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Vydáno v:Chem Sci
Hlavní autoři: McAllister, T. E., Yeh, T.-L., Abboud, M. I., Leung, I. K. H., Hookway, E. S., King, O. N. F., Bhushan, B., Williams, S. T., Hopkinson, R. J., Münzel, M., Loik, N. D., Chowdhury, R., Oppermann, U., Claridge, T. D. W., Goto, Y., Suga, H., Schofield, C. J., Kawamura, A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2018
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969509/
https://ncbi.nlm.nih.gov/pubmed/29899950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc00286j
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