Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

Insufficient autophagy in podocytes is related to podocyte injury in diabetic nephropathy (DN). Advanced glycation end‐products (AGEs) are major factors of podocyte injury in DN. However, the role and mechanism of AGEs in autophagic dysfunction remain unknown. We investigated autophagic flux in AGE‐...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Zhao, Xingchen, Chen, Yuanhan, Tan, Xiaofan, Zhang, Li, Zhang, Hong, Li, Zhilian, Liu, Shuangxin, Li, Ruizhao, Lin, Ting, Liao, Ruyi, Zhang, Qianmei, Dong, Wei, Shi, Wei, Liang, Xinling
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2018
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969319/
https://ncbi.nlm.nih.gov/pubmed/29570219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5077
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