Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

Insufficient autophagy in podocytes is related to podocyte injury in diabetic nephropathy (DN). Advanced glycation end‐products (AGEs) are major factors of podocyte injury in DN. However, the role and mechanism of AGEs in autophagic dysfunction remain unknown. We investigated autophagic flux in AGE‐...

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Библиографические подробности
Опубликовано в: :J Pathol
Главные авторы: Zhao, Xingchen, Chen, Yuanhan, Tan, Xiaofan, Zhang, Li, Zhang, Hong, Li, Zhilian, Liu, Shuangxin, Li, Ruizhao, Lin, Ting, Liao, Ruyi, Zhang, Qianmei, Dong, Wei, Shi, Wei, Liang, Xinling
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley & Sons, Ltd 2018
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Original Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969319/
https://ncbi.nlm.nih.gov/pubmed/29570219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5077
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