Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

The recent identification of profilin1 mutations in 25 familial ALS cases has linked altered function of this cytoskeleton-regulating protein to the pathogenesis of motor neuron disease. To investigate the pathological role of mutant profilin1 in motor neuron disease, we generated transgenic lines o...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Fil, Daniel, DeLoach, Abigail, Yadav, Shilpi, Alkam, Duah, MacNicol, Melanie, Singh, Awantika, Compadre, Cesar M., Goellner, Joseph J., O’Brien, Charles A., Fahmi, Tariq, Basnakian, Alexei G., Calingasan, Noel Y., Klessner, Jodi L., Beal, Flint M., Peters, Owen M., Metterville, Jake, Brown, Robert H., Ling, Karen K.Y., Rigo, Frank, Ozdinler, P. Hande, Kiaei, Mahmoud
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968635/
https://ncbi.nlm.nih.gov/pubmed/28040732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw429
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