Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson’s disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine...

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Detalhes bibliográficos
Main Authors: Li, Yanping, Liu, Wencheng, Oo, Tinmarla F, Wang, Lei, Tang, Yi, Jackson-Lewis, Vernice, Zhou, Chun, Geghman, Kindiya, Bogdanov, Mikhail, Przedborski, Serge, Beal, M Flint, Burke, Robert E, Li, Chenjian
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845930/
https://ncbi.nlm.nih.gov/pubmed/19503083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2349
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