Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson’s disease features and enhances vulnerability to mitochondrial impairment

Parkinson’s disease (PD), the second most common neurodegenerative disorder, is etiologically heterogeneous, with most cases thought to arise from a combination of environmental factors and genetic predisposition; about 10% of cases are caused by single gene mutations. While neurotoxin models replic...

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Detalhes bibliográficos
Main Authors: Cannon, Jason R., Geghman, Kindiya D., Tapias, Victor, Sew, Thomas, Dail, Michelle K., Li, Chenjian, Greenamyre, J. Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552027/
https://ncbi.nlm.nih.gov/pubmed/23153578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.11.007
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