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Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

α-Synuclein (α-Syn) is enriched in nerve terminals. Two mutations in the α-Syn gene (Ala53→ Thr and Ala30→ Pro) occur in autosomal dominant familial Parkinson's disease. Mice overexpressing the human A53T mutant α-Syn develop a severe movement disorder, paralysis, and synucleinopathy, but the m...

詳細記述

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書誌詳細
出版年:J Neurosci
主要な著者: Martin, Lee J., Pan, Yan, Price, Ann C., Sterling, Wanda, Copeland, Neal G., Jenkins, Nancy A., Price, Donald L., Lee, Michael K.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381830/
https://ncbi.nlm.nih.gov/pubmed/16399671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4308-05.2006
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