An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications

Sequestering peptides derived from the N-terminal heptad repeat (NHR) of class I viral fusion proteins into a non-aggregating trimeric coiled-coil conformation remains a major challenge. Here, we implemented a synthetic strategy to stabilize NHR-helical trimers, with the human immunodeficiency virus...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Lai, Wenqing, Wang, Chao, Yu, Fei, Lu, Lu, Wang, Qian, Jiang, Xifeng, Xu, Xiaoyu, Zhang, Tianhong, Wu, Shengming, Zheng, Xi, Zhang, Zhenqing, Dong, Fangting, Jiang, Shibo, Liu, Keliang
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5968561/
https://ncbi.nlm.nih.gov/pubmed/29899942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04046a
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