A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers

ABSTRACT Native-like HIV-1 envelope glycoprotein (Env) trimers, exemplified by the SOSIP design, are widely used as immunogens, analytical antigens, and for structural studies. These vaccine research and development programs require trimers that are based on multiple HIV-1 genotypes. While a wide ra...

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Main Authors: Devidas N. Chaturbhuj, Kwinten Sliepen, Albert Cupo, Benjamin Steinberg, Simon Kazimierczyk, Tarek Munawar, Kyle Kramer, Anila Yasmeen, Thales G. Andrade, Wen-Hsin Lee, Lara van der Maas, Grace Gibson, Oscar Feliciano, Ivan del Moral Sanchez, Edith Schermer, Rhianna Bronson, Alison Benner, Madhu Prabhakaran, Rosemarie Mason, P. J. Klasse, Andrew B. Ward, Gabriel Ozorowski, Rogier W. Sanders, John P. Moore
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2025-09-01
Serija:Journal of Virology
Teme:
HIV-1
SOSIP
trimer
gp41
heptad repeat
Env glycoprotein
Online dostop:https://journals.asm.org/doi/10.1128/jvi.00913-25
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