Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered t...

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Pubblicato in:Sci Rep
Autori principali: Wang, Chao, Li, Xue, Yu, Fei, Lu, Lu, Jiang, Xifeng, Xu, Xiaoyu, Wang, Huixin, Lai, Wenqing, Zhang, Tianhong, Zhang, Zhenqing, Ye, Ling, Jiang, Shibo, Liu, Keliang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999862/
https://ncbi.nlm.nih.gov/pubmed/27562370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32161
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