An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

N-methyl-d-aspartate receptors (NMDARs) are an important receptor in the brain and have been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting drugs are poorly tolerated, leading to efforts to target NMDAR subtypes to improve the therapeutic index. We describe here a...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Perszyk, Riley, Katzman, Brooke M, Kusumoto, Hirofumi, Kell, Steven A, Epplin, Matthew P, Tahirovic, Yesim A, Moore, Rhonda L, Menaldino, David, Burger, Pieter, Liotta, Dennis C, Traynelis, Stephen F
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2018
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967867/
https://ncbi.nlm.nih.gov/pubmed/29792594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34711
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