Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates

Topical microbicides are being explored as an HIV prevention method for individuals who practice receptive anal intercourse. In vivo studies of these microbicides are critical to confirm safety. Here, we evaluated the impact of a rectal microbicide containing the antiviral lectin, Griffithsin (GRFT)...

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Publicado en:Sci Rep
Autores principales: Girard, Lauren, Birse, Kenzie, Holm, Johanna B., Gajer, Pawel, Humphrys, Mike S., Garber, David, Guenthner, Patricia, Noël-Romas, Laura, Abou, Max, McCorrister, Stuart, Westmacott, Garrett, Wang, Lin, Rohan, Lisa C., Matoba, Nobuyuki, McNicholl, Janet, Palmer, Kenneth E., Ravel, Jacques, Burgener, Adam D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966460/
https://ncbi.nlm.nih.gov/pubmed/29795295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26313-8
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