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Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa

Natural-product derived lectins can function as potent viral inhibitors with minimal toxicity as shown in vitro and in small animal models. We here assessed the effect of rectal application of an anti-HIV lectin-based microbicide Q-Griffithsin (Q-GRFT) in rectal tissue samples from rhesus macaques....

詳細記述

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書誌詳細
出版年:Sci Rep
主要な著者: Günaydın, Gökçe, Edfeldt, Gabriella, Garber, David A., Asghar, Muhammad, Noȅl-Romas, Laura, Burgener, Adam, Wählby, Carolina, Wang, Lin, Rohan, Lisa C., Guenthner, Patricia, Mitchell, James, Matoba, Nobuyuki, McNicholl, Janet M., Palmer, Kenneth E., Tjernlund, Annelie, Broliden, Kristina
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889265/
https://ncbi.nlm.nih.gov/pubmed/31792342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54493-4
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