Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa

Natural-product derived lectins can function as potent viral inhibitors with minimal toxicity as shown in vitro and in small animal models. We here assessed the effect of rectal application of an anti-HIV lectin-based microbicide Q-Griffithsin (Q-GRFT) in rectal tissue samples from rhesus macaques....

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Günaydın, Gökçe, Edfeldt, Gabriella, Garber, David A., Asghar, Muhammad, Noȅl-Romas, Laura, Burgener, Adam, Wählby, Carolina, Wang, Lin, Rohan, Lisa C., Guenthner, Patricia, Mitchell, James, Matoba, Nobuyuki, McNicholl, Janet M., Palmer, Kenneth E., Tjernlund, Annelie, Broliden, Kristina
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889265/
https://ncbi.nlm.nih.gov/pubmed/31792342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54493-4
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