Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates

Topical microbicides are being explored as an HIV prevention method for individuals who practice receptive anal intercourse. In vivo studies of these microbicides are critical to confirm safety. Here, we evaluated the impact of a rectal microbicide containing the antiviral lectin, Griffithsin (GRFT)...

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Publicat a:Sci Rep
Autors principals: Girard, Lauren, Birse, Kenzie, Holm, Johanna B., Gajer, Pawel, Humphrys, Mike S., Garber, David, Guenthner, Patricia, Noël-Romas, Laura, Abou, Max, McCorrister, Stuart, Westmacott, Garrett, Wang, Lin, Rohan, Lisa C., Matoba, Nobuyuki, McNicholl, Janet, Palmer, Kenneth E., Ravel, Jacques, Burgener, Adam D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966460/
https://ncbi.nlm.nih.gov/pubmed/29795295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26313-8
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