Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates

Topical microbicides are being explored as an HIV prevention method for individuals who practice receptive anal intercourse. In vivo studies of these microbicides are critical to confirm safety. Here, we evaluated the impact of a rectal microbicide containing the antiviral lectin, Griffithsin (GRFT)...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Girard, Lauren, Birse, Kenzie, Holm, Johanna B., Gajer, Pawel, Humphrys, Mike S., Garber, David, Guenthner, Patricia, Noël-Romas, Laura, Abou, Max, McCorrister, Stuart, Westmacott, Garrett, Wang, Lin, Rohan, Lisa C., Matoba, Nobuyuki, McNicholl, Janet, Palmer, Kenneth E., Ravel, Jacques, Burgener, Adam D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966460/
https://ncbi.nlm.nih.gov/pubmed/29795295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26313-8
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