Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition

Despite recent progress in the treatment, the outcome of adult acute T-cell lymphoblastic leukemia (T-ALL) is poor. Development of novel approach to combat this disease is urgently required. Vorinostat, a pan-histone deacetylase (HDAC) inhibitor, exerts promising anticancer activity in a variety of...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Jing, Bo, Jin, Jin, Xiang, Rufang, Liu, Meng, Yang, Li, Tong, Yin, Xiao, Xinhua, Lei, Hu, Liu, Wei, Xu, Hanzhang, Deng, Jiong, Zhou, Li, Wu, Yingli
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964102/
https://ncbi.nlm.nih.gov/pubmed/29789603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0679-6
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