Wird geladen...

USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway. Recent studies have revealed that posttranslational modifications, such as ubiquitination, regulate NOTCH1 stability, activity, and localizatio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Signal Transduct Target Ther
Hauptverfasser: Shan, Huizhuang, Li, Xiangyun, Xiao, Xinhua, Dai, Yuting, Huang, Jinyan, Song, Junjun, Liu, Meng, Yang, Li, Lei, Hu, Tong, Yin, Zhou, Li, Xu, Hanzhang, Wu, Yingli
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202415/
https://ncbi.nlm.nih.gov/pubmed/30370059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-018-0028-3
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!