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USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway. Recent studies have revealed that posttranslational modifications, such as ubiquitination, regulate NOTCH1 stability, activity, and localizatio...
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| 出版年: | Signal Transduct Target Ther |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202415/ https://ncbi.nlm.nih.gov/pubmed/30370059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-018-0028-3 |
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