USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway. Recent studies have revealed that posttranslational modifications, such as ubiquitination, regulate NOTCH1 stability, activity, and localizatio...

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Pubblicato in:Signal Transduct Target Ther
Autori principali: Shan, Huizhuang, Li, Xiangyun, Xiao, Xinhua, Dai, Yuting, Huang, Jinyan, Song, Junjun, Liu, Meng, Yang, Li, Lei, Hu, Tong, Yin, Zhou, Li, Xu, Hanzhang, Wu, Yingli
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202415/
https://ncbi.nlm.nih.gov/pubmed/30370059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-018-0028-3
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