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USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway. Recent studies have revealed that posttranslational modifications, such as ubiquitination, regulate NOTCH1 stability, activity, and localizatio...
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| Publié dans: | Signal Transduct Target Ther |
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| Auteurs principaux: | , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202415/ https://ncbi.nlm.nih.gov/pubmed/30370059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-018-0028-3 |
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