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Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells

Histone deacetylase inhibitors (HDACi) are promising anti-cancer agents, however, their mechanisms of action remain unclear. In acute myeloid leukemia (AML) cells, HDACi have been reported to arrest growth and induce apoptosis. In this study, we elucidate details of the DNA damage induced by the HDA...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Petruccelli, Luca A., Dupéré-Richer, Daphné, Pettersson, Filippa, Retrouvey, Hélène, Skoulikas, Sophia, Miller, Wilson H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112218/
https://ncbi.nlm.nih.gov/pubmed/21695163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020987
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