Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells

Histone deacetylase inhibitors (HDACi) are promising anti-cancer agents, however, their mechanisms of action remain unclear. In acute myeloid leukemia (AML) cells, HDACi have been reported to arrest growth and induce apoptosis. In this study, we elucidate details of the DNA damage induced by the HDA...

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Detaylı Bibliyografya
Asıl Yazarlar: Petruccelli, Luca A., Dupéré-Richer, Daphné, Pettersson, Filippa, Retrouvey, Hélène, Skoulikas, Sophia, Miller, Wilson H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112218/
https://ncbi.nlm.nih.gov/pubmed/21695163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020987
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