Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type-2 Allergic Inflammation

Ras, a small GTPase protein, is thought to mediate Th2-dependent eosinophilic inflammation in asthma. Ras requires cell membrane association for its biological activity and this requires the post-translational modification of Ras with an isoprenyl group by farnesyltransferase (FTase) or geranylgeran...

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Bibliographic Details
Published in:J Immunol
Main Authors: Bratt, Jennifer M., Chang, Kevin Y., Rabowsky, Michelle, Franzi, Lisa M., Ott, Sean P., Filosto, Simone, Goldkorn, Tzipora, Arif, Muhammad, Last, Jerold A., Kenyon, Nicholas J., Zeki, Amir A.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964018/
https://ncbi.nlm.nih.gov/pubmed/29703864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601317
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