The TLR4 agonist monophosphoryl lipid A drives broad resistance to infection via dynamic reprogramming of macrophage metabolism

Monophosphoryl lipid A (MPLA) is a clinically utilized toll-like receptor (TLR) 4 agonist that has been found to drive non-specific resistance to infection for up to two weeks. However, the molecular mechanisms conferring protection are not well understood. Here, we found that MPLA prompts resistanc...

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Udgivet i:J Immunol
Main Authors: Fensterheim, Benjamin A., Young, Jamey D., Luan, Liming, Kleinbard, Ruby R., Stothers, Cody L., Patil, Naeem K., McAtee-Pereira, Allison G., Guo, Yin, Trenary, Irina, Hernandez, Antonio, Fults, Jessica B., Williams, David L., Sherwood, Edward R., Bohannon, Julia K.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964009/
https://ncbi.nlm.nih.gov/pubmed/29686054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800085
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