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Comparative Antitumor Activity and Intestinal Toxicity of 5′‐Deoxy‐5‐fluorouridine and Its Prodrug Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine

N(4)‐Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine (Ro 09–1390), a prodrug of the cytostatic 5′‐deoxy‐5‐fluorouridine (5′‐DFUR), was synthesized with the aim of reducing of the dose‐limiting toxicity of 5′‐DFUR, which is diarrhea. In mice bearing Lewis lung carcinoma, 5′‐DFUR given po produced a subst...

詳細記述

保存先:
書誌詳細
出版年:Jpn J Cancer Res
主要な著者: Ninomiya, Yasuyuki, Miwa, Masanori, Eda, Hiroyuki, Sahara, Hiroshi, Fujimoto, Kaori, Ishida, Masako, Umeda, Isao, Yokose, Kazuteru, Ishitsuka, Hideo
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Publishing Ltd 1990
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963899/
https://ncbi.nlm.nih.gov/pubmed/2139643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1990.tb02547.x
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