Pharmacokinetics and bioavailability of oral 5′-deoxy-5-fluorouridine in cancer patients

AIMS: Oral administration of 5-fluorouracil (FUra), an important cytotoxic agent, is limited by a wide variation in bioavailability. 5′-deoxy-5-fluorouridine (dFUrd), a masked form of FUra, has shown promise clinically when given intravenously or orally as a solution or tablet. This study investigat...

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Autores principales: Van Der Heyden, S A M, Highley, M S, De Bruijn, E A, Tjaden, U R, Reeuwijk, H J E M, Van Slooten, H, Van Oosterom, A T, Maes, R A A
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 1999
Materias:
Drug Delivery
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014244/
https://ncbi.nlm.nih.gov/pubmed/10233196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00899.x
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