Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.

Four human head and neck xenograft (HNX) tumour lines grown in nude mice and two murine colon carcinomas (Colon 26 and 38) were tested for their sensitivity to 5-fluorouracil (5-FU) and its prodrug 5'deoxy-5-fluorouridine (Doxifluridine, 5'd-FUR). 5-FU sensitivity at the maximum tolerated...

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Main Authors: Peters, G. J., Braakhuis, B. J., de Bruijn, E. A., Laurensse, E. J., van Walsum, M., Pinedo, H. M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1989
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2247094/
https://ncbi.nlm.nih.gov/pubmed/2522792
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