Comparative Antitumor Activity and Intestinal Toxicity of 5′‐Deoxy‐5‐fluorouridine and Its Prodrug Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine

N(4)‐Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine (Ro 09–1390), a prodrug of the cytostatic 5′‐deoxy‐5‐fluorouridine (5′‐DFUR), was synthesized with the aim of reducing of the dose‐limiting toxicity of 5′‐DFUR, which is diarrhea. In mice bearing Lewis lung carcinoma, 5′‐DFUR given po produced a subst...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Ninomiya, Yasuyuki, Miwa, Masanori, Eda, Hiroyuki, Sahara, Hiroshi, Fujimoto, Kaori, Ishida, Masako, Umeda, Isao, Yokose, Kazuteru, Ishitsuka, Hideo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1990
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963899/
https://ncbi.nlm.nih.gov/pubmed/2139643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1990.tb02547.x
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