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TALEN-Mediated FLAG-Tagging of Endogenous Histone Methyltransferase DOT1L
Histone modification including H3 lysine 79 methylation (H3K79me) plays a key role during gene transcription and DNA damage repair. DOT1L, the sole methyltransferase for three states of H3K79me, is implicated in leukemia, co-lorectal cancer, and dilated cardiomyopathy. However, understanding of DOT1...
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| Publicado en: | Adv Biosci Biotechnol |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5963693/ https://ncbi.nlm.nih.gov/pubmed/29796335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/abb.2017.89023 |
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