TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast

The events underlying senescence induced by critical telomere shortening are not fully understood. Here we provide evidence that TERRA, a non-coding RNA transcribed from subtelomeres, contributes to senescence in yeast lacking telomerase (tlc1Δ). Levels of TERRA expressed from multiple telomere ends...

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Publicat a:PLoS One
Autors principals: Wanat, Jennifer J., Logsdon, Glennis A., Driskill, Jordan H., Deng, Zhong, Lieberman, Paul M., Johnson, F. Brad
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896980/
https://ncbi.nlm.nih.gov/pubmed/29649255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195698
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