TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast

The events underlying senescence induced by critical telomere shortening are not fully understood. Here we provide evidence that TERRA, a non-coding RNA transcribed from subtelomeres, contributes to senescence in yeast lacking telomerase (tlc1Δ). Levels of TERRA expressed from multiple telomere ends...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Wanat, Jennifer J., Logsdon, Glennis A., Driskill, Jordan H., Deng, Zhong, Lieberman, Paul M., Johnson, F. Brad
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896980/
https://ncbi.nlm.nih.gov/pubmed/29649255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195698
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