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TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast
The events underlying senescence induced by critical telomere shortening are not fully understood. Here we provide evidence that TERRA, a non-coding RNA transcribed from subtelomeres, contributes to senescence in yeast lacking telomerase (tlc1Δ). Levels of TERRA expressed from multiple telomere ends...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5896980/ https://ncbi.nlm.nih.gov/pubmed/29649255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195698 |
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