Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension

The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In lung this can manifest as capillary leakage with pleural effusion, pulmonary edema or even pulmonary arterial hypertension. To understand ho...

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Bibliografische gegevens
Gepubliceerd in:Front Physiol
Hoofdauteurs: Fazakas, Csilla, Nagaraj, Chandran, Zabini, Diana, Végh, Attila G., Marsh, Leigh M., Wilhelm, Imola, Krizbai, István A., Olschewski, Horst, Olschewski, Andrea, Bálint, Zoltán
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Physiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962749/
https://ncbi.nlm.nih.gov/pubmed/29867576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00537
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