Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension

The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In lung this can manifest as capillary leakage with pleural effusion, pulmonary edema or even pulmonary arterial hypertension. To understand ho...

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Vydáno v:Front Physiol
Hlavní autoři: Fazakas, Csilla, Nagaraj, Chandran, Zabini, Diana, Végh, Attila G., Marsh, Leigh M., Wilhelm, Imola, Krizbai, István A., Olschewski, Horst, Olschewski, Andrea, Bálint, Zoltán
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962749/
https://ncbi.nlm.nih.gov/pubmed/29867576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00537
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