Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension

The multi-kinase inhibitor dasatinib is used for treatment of imatinib-resistant chronic myeloid leukemia, but is prone to induce microvascular dysfunction. In lung this can manifest as capillary leakage with pleural effusion, pulmonary edema or even pulmonary arterial hypertension. To understand ho...

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Pubblicato in:Front Physiol
Autori principali: Fazakas, Csilla, Nagaraj, Chandran, Zabini, Diana, Végh, Attila G., Marsh, Leigh M., Wilhelm, Imola, Krizbai, István A., Olschewski, Horst, Olschewski, Andrea, Bálint, Zoltán
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962749/
https://ncbi.nlm.nih.gov/pubmed/29867576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00537
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