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Mechanism of NMDA receptor channel block by MK-801 and memantine
The N-methyl-D-aspartate (NMDA) receptor transduces the binding of glutamate and glycine into the opening of a calcium-permeable ion channel(1). Because the NMDA receptor has proven recalcitrant to high resolution structural studies, the mechanism by which ion channel blockers occlude ion permeation...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5962351/ https://ncbi.nlm.nih.gov/pubmed/29670280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0039-9 |
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