Mechanism of NMDA receptor channel block by MK-801 and memantine

The N-methyl-D-aspartate (NMDA) receptor transduces the binding of glutamate and glycine into the opening of a calcium-permeable ion channel(1). Because the NMDA receptor has proven recalcitrant to high resolution structural studies, the mechanism by which ion channel blockers occlude ion permeation...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Song, Xianqiang, Jensen, Morten Ø., Jogini, Vishwanath, Stein, Richard A., Lee, Chia-Hsueh, Mchaourab, Hassane S., Shaw, David E., Gouaux, Eric
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962351/
https://ncbi.nlm.nih.gov/pubmed/29670280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0039-9
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