Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg(2+) and memantine under conditions of agonist exposure

MK-801 is a use-dependent NMDA receptor open channel blocker with a very slow off-rate. These properties can be exploited to ‘pre-block’ a population of NMDARs, such as synaptic ones, enabling the selective activation of a different population, such as extrasynaptic NMDARs. However, the usefulness o...

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Main Authors: McKay, Sean, Bengtson, C. Peter, Bading, Hilmar, Wyllie, David J.A., Hardingham, Giles E.
Formato: Artigo
Idioma:Inglês
Publicado: Pergamon Press 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778432/
https://ncbi.nlm.nih.gov/pubmed/23402996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.01.024
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