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Structural basis for recognition of diverse antidepressants by the human serotonin transporter
Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by increasing the local concentration of neurotransmitter at synapses and in extracellular spaces via blockade of the serotonin transporter. Here we report x-ray structures of engineered thermostable variants...
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| Pubblicato in: | Nat Struct Mol Biol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5962350/ https://ncbi.nlm.nih.gov/pubmed/29379174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0026-8 |
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