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Structural basis for recognition of diverse antidepressants by the human serotonin transporter

Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by increasing the local concentration of neurotransmitter at synapses and in extracellular spaces via blockade of the serotonin transporter. Here we report x-ray structures of engineered thermostable variants...

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Bibliografiske detaljer
Udgivet i:Nat Struct Mol Biol
Main Authors: Coleman, Jonathan A., Gouaux, Eric
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962350/
https://ncbi.nlm.nih.gov/pubmed/29379174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0026-8
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