Synaptotagmin 4 regulates pancreatic β-cell maturation by modulating the Ca(2+) sensitivity of insulin secretion vesicles

Islet β-cells from newborn mammals exhibit high basal insulin secretion and poor glucose-stimulated-insulin-secretion (GSIS). Here we show that β cells of newborns secrete more insulin than adults in response to similar intracellular Ca(2+) concentrations, suggesting differences in the Ca(2+) sensit...

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Publicado en:Dev Cell
Main Authors: Huang, Chen, Walker, Emily M., Dadi, Prasanna K., Hu, Ruiying, Xu, Yanwen, Zhang, Wenjian, Sanavia, Tiziana, Mun, Jisoo, Liu, Jennifer, Nair, Gopika G., Yim Angeline, Tan Hwee, Wang, Sui, Magnuson, Mark A., Stoeckert, Christian J., Hebrok, Matthias, Gannon, Maureen, Han, Weiping, Stein, Roland, Jacobson, David A., Gu, Guoqiang
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962294/
https://ncbi.nlm.nih.gov/pubmed/29656931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.03.013
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