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Polypharmacology Within the Full Kinome: a Machine Learning Approach

Protein kinases generate nearly a thousand different protein products and regulate the majority of cellular pathways and signal transduction. It is therefore not surprising that the deregulation of kinases has been implicated in many disease states. In fact, kinase inhibitors are the largest class o...

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Bibliografske podrobnosti
izdano v:AMIA Jt Summits Transl Sci Proc
Main Authors: Jones, Derek, Bopaiah, Jeevith, Alghamedy, Fatemah, Jacobs, Nathan, Weiss, Heidi L., de Jong, W.A., Ellingson, Sally R.
Format: Artigo
Jezik:Inglês
Izdano: American Medical Informatics Association 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961802/
https://ncbi.nlm.nih.gov/pubmed/29888050
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