Visualizing structure-mediated interactions in supercoiled DNA molecules

We directly visualize the topology-mediated interactions between an unwinding site on a supercoiled DNA plasmid and a specific probe molecule designed to bind to this site, as a function of DNA supercoiling and temperature. The visualization relies on containing the DNA molecules within an enclosed...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Scott, Shane, Xu, Zhi Ming, Kouzine, Fedor, Berard, Daniel J, Shaheen, Cynthia, Gravel, Barbara, Saunders, Laura, Hofkirchner, Alexander, Leroux, Catherine, Laurin, Jill, Levens, David, Benham, Craig J, Leslie, Sabrina R
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961182/
https://ncbi.nlm.nih.gov/pubmed/29684182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky266
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