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Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef

The HIV type 1 pathogenicity factor Nef enhances viral replication by modulating multiple host cell pathways, including tuning the activation state of infected CD4 T lymphocytes to optimize virus spread. For this, Nef inhibits anterograde transport of the Src family kinase (SFK) Lck toward the plasm...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chase, Amanda J., Wombacher, Rebecka, Fackler, Oliver T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961038/
https://ncbi.nlm.nih.gov/pubmed/29588370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002794
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